status epilepticus (continuous seizures without recovery of consciousness between attacks), multi-organ dysfunction and Disseminated Intravascular Coagulation or DIC. The contribution of Lamotrigine to these events remains to be established".

However, a case of Stevens-Johnson Syndrome has been associated with Lamotrigine as well as three cases of multi-organ failure through its use in recent years (The Lancet, August 13, 1994).

Liver damage has also been linked with Epilim, particularly in children and those with mental retardation, and although this is rare, these drugs become more dangerous if used together. The 35-year-old, mentally handicapped son of one WDDTY reader used to take Epilim, Tegretol and folic acid every day, but died after he'd been prescribed a daily 50mg tablet of Lamictal.

!AClive Couldwell